Publications
Lab Gloria Borgstahl Biochemistry Eppley UNMC Links

Up

Publications

bulletBorgstahl, G. E. O., Brader, K., Mosel, A., Liu, S., Kremmer, E., Goettsch, K.A., Kolar, C., Nasheuer, H.P., Oakley, G.G., "Interplay of DNA damage and cell cycle signaling at the level of human Replication Protein A" DNA Repair 21, 12-23 (2014).
Available in PDF
 
bulletSimone, P., Stuble, L. R., Kellezi, A., Brown, C. A., Garbow, C. E., Khutsishvili, I., Marky, L. A., Pavlov, Y. I., and Borgstahl, G. E. O. "The human ITPA polymorphic variant P32T is destabilized by the unpacking of the hydrophobic core" J. Structural Biology 182. 197-208 (2013).
Available in PDF
 
bulletKumar, E., Chen, Q., Kizhake, S., Kolar, C., Kang, M., Chang, C, Borgstahl, G. E. O., and Natarajan, A. "The paradox of conformational constraints in the design of Cbl(TKB)-binding peptides" Scientific Reports 3, 1639 (2013).
Available in PDF
 
bulletSimone, P., Pavlov, Y. I., and Borgstahl, G. E. O. "ITPA (inosine triphosphate pyrophatase): From surveillance of nucleotide pools to human disease and pharmacogenetics" Mutation Research 753, 131-146 (2013)
Available in PDF
 
bulletLovelace, J.J., Simone, P.D., Petricek, V., and Borgstahl, G.E.O. "Simulation of modulated protein crystal structure and diffraction data in a supercell and in superspace" Acta Crystallographica Section D: Biological Crystallography, 2013, Volume D69, pages 1062-1072.
Available in PDF
 
bulletKumar, E. A., Yuan, Z., Palermo, N. Y., Dong, L., Ahmad, G., Lokesh, G. L., Kolar, C., Kizahk, S., Borgstahl, G. E. O., Band, H., and Natarajan, A. "Peptide truncation leads to a twist and an unusual increase in affinity for Cbl tyrosine kinase binding domain" J. Med. Chem. 55, 3583-3597 (2012).
Available in PDF
 
bulletMohapatra, B., Ahmad, G., Nadeau, S., Zutshi, N., Ang, W., Scheffee, S., Dong, L., Feng, D., Goetz, B., Arya, P., Baily, T. A., Palermo, N., Borgstahl, G. E. O., Natarajan, A., Raja, S., Naramura, M., Band, V., and Band, H. "Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases" Molecular Cell Research 1833, 122-139 (2012).
Available in PDF
 
bulletNadeau, S., An, W., Palermo, N., Feng, D., Ahmad, G., Dong, L., Borgstahl, G. E. O., Nararajan, A., Naramura, M., Band, V., and Band, H. "Oncogenic signaling by leukemia-associated mutant Cbl proteins" Biochemistry and Analytical Biochemistry 6, 7921 (2012).
Available in PDF
 
bulletPorta, J.C. and Borgstahl, G.E.O. "Structural Basis for Profilin-Mediated Actin Nucleotide Exchange" J. Mol. Biol. (2012) 418, 103-116.
Available in PDF
 
bulletPrakash, A. and Borgstahl, G.E.O. "The Structure and Function of Replication Protein A in DNA Replication" Invited Review for The Eukaryotic Replisome: A Guide to Protein Structure and Function, Subcellular Biochemistry 62, 103-116 (2012).
Available in PDF
 
bulletBao, B., Pestinger, V., Hassan, Y. I., Borgstahl, G. E. O., Kolar, C., and Zempleni, J. "Holocarboxylase synthetase is a chromatin protein and interacts directly with histone H3 to mediate biotinylation of K9 and K18" J. Nutr. Biochem. 22, 470-475 (2011).
Available in PDF
 
bulletLada, A. G., Waisertreiger, I. S.-R., Grabow, C. E., Prakash, A., Borgstahl, G. E. O, Rogozin, I. B., and Pavlov, Y. I. "Replication protein A (RPA) hampers the processive action of APOBEC3G cytosine deaminase on single-stranded DNA" PLoS ONE 6, e24848 (2011).
Available in PDF
 
bulletJason Porta, Jeffrey J. Lovelace, Antoine M. M. Schreurs, Loes M. J. Kroon-Batenburg and Gloria E. O. Borgstahl "Processing incommensurately modulated protein diffraction data with EVAL15", Acta Cryst. D67, 628-638 (2011).
Available in PDF

Errata for Porta, et. al.
Available in PDF
 

bulletPrakash, A., Kieken, F., Marky, L. A., and Borgstahl, G. E. O. "Stabilization of a G-quadruplex from unfolding by Replication Protein A using potassium and the porphyrin TMPyP4" J. Nucleic Acids 2011, Article ID 529828, 13 pages (2011).
Available in PDF
 
bulletPrakash, A., Natarajan, A., Marky, L. A., Ouellette, M. M. and Borgstahl, G. E. O. "Identification of the DNA binding domains of human Replication Protein A that recognize G-quadruplex DNA" J. Nucleic Acids 2011, Article ID 896947, 14 pages (2011).
Available in PDF
 
bulletNina A. Filenko, Carol Kolar, John T. West, S. Abbie Smith, Yousef I. Hassan, Gloria E. O. Borgstahl, Janos Zempleni, Yuri L. Lyubchenko "The Role of Histone H4 Biotinylation in the Structure of Nucleosomes" Plos One 6, 1-7 (2011).
Available in PDF
 
bulletJodi L. Kreiling, Kerry Brader, Carol Kolar, and Gloria E. O. Borgstahl "A Real-Time and Hands-On Research Course in Protein Purification and Characterization" Biochemistry and Molecular Biology Education Journal 39, 28-37 (2011).
Available in PDF
 
bulletJeffrey J. Lovelace and Gloria E. O. Borgstahl, "The use of orthogonal projection to visualize mosaic domains from topographic data collected on protein crystals", Journal of Applied Crystallography, 2010, Volume 43, pages 907-912.
Available in PDF
 
bulletMichael G. Kemp, Aaron C. Mason, Aura Carreira, Joyce T. Reardon, Stuart J. Haring, Gloria E. O. Borgstahl, Stephen C. Kowalczykowski, Aziz Sancar and Marc S. Wold, "An Alternative Form of Replication Protein A Expressed in Normal Human Tissues Supports DNA Repair", The Journal of Biological Chemistry vol. 285, no. 7, pp. 4788-4797, February 12, 2010.
Available in PDF
 
bulletJason Porta, Ardeschir Vahedi-Faridi and Gloria E. O. Borgstahl, "Structural Analysis of Peroxide-Soaked MnSOD Crystals Reveals Side-On Binding of Peroxide to Active-Site Manganese", J. Mol. Biol. (2010) 399, 377-384.
Available in PDF
 
bulletJeffrey J. Lovelace, Martyn D. Winn and Gloria E. O. Borgstahl, "Simulation of modulated reflections", Journal of Applied Crystallography, 2010, Volume 43, pages 285-292 (2010).
Available in PDF
 
bulletElena I. Stepchenkova, Elena R. Tarakhovskaya, Kathryn Spitler, Christin Frahm, Miriam R. Menezes, Peter D. Simone, Carol Kolar, Luis A. Marky, Gloria E. O. Borgstahl and Youri I. Pavlov, "Functional Study of the P32T ITPA Variant Associated with Drug Sensitivity in Humans", J. Mol. Biol. (2009) 392, 602-613.
Available in PDF
 
bulletX. Deng, A. Prakash, K. Dhar, G. S. Baia, C.l Kolar, G. G. Oakley and G. E. O. Borgstahl, "Human Replication Protein A−Rad52−Single-Stranded DNA Complex: Stoichiometry and Evidence for Strand Transfer Regulation by Phosphorylation", Biochemistry (2009).
Online Here and Available in PDF (Need to login to ACS website)
 
bulletBorgstahl, G. E. O. "Incommensurate Crystallography by Sander van Smaalen", Crystallography reviews 14 , 259-260 (2008).
Available in PDF
 
bulletKellezi, A., Kieken, F., Grosely, R., Borgstahl, G. E. O. , and Sorgen, P. L., "Purification of the Connexin43 Carboxyl Terminus attached to the 4 th Transmembrane Domain" Protein Expression and Purification 59 , 215-222 (2008).
Available in PDF
 
bulletLovelace, J. J., Murphy, C. R., Narayan, K., Schutt, C. E., Lindberg, U., Svensson, C., Wynn, M., and Borgstahl , G. E. O., "Protein crystals can be incommensurately modulated" J. Appl. Cryst. 41 , 600-605 (2008). Copyright © International Union of Crystallography
Available in PDF
 
bulletD. H. Juers, J. J. Lovelace, H. D. Bellamy, E. H. Snell, B. W. Mathews and G. E. O. Borgstahl, "Changes to crystals of Escherichia coli β-galactosidase during room-temperature/low-temperature cycling and their relation to cryo-annealing", Acta Cryst. (2007). D63, 1139-1153 Copyright © International Union of Crystallography.
Available in PDF
 
bulletX. Deng, J. E. Habel, V. Kabaleeswaran, E. H. Snell, M. S. Wold and G. E. O. Borgstahl, "Structure of the Full-length Human RPA14/32 Complex Gives Insights into the Mechanism of DNA Binding and Complex Formation", J. Mol. Biol. (2007) 374, 865-876.
Available in PDF
 
bulletE. Yikilmaz, J. Porta, L. E. Grove, A. Vahedi-Faridi, Y. Bronshteyn, T. C. Brunold, G. E. O. Borgstahl and A. Miller, "How Can Single Second Sphere Amino Acid Substitution Cause Reduction Midpoint Potential Changes of Hundreds of Millivolts?", J. Am. Chem. Soc., 129(32), 9927-9940, 2007.
Available in PDF
 
bulletBorgstahl, G. E. O., "How to Use of Dynamic Light Scattering to Improve the Likelihood of Growing Macromolecular Crystals" Invited Chapter in Macromolecular Crystallography Protocols, 1 , 109-129, (2006).
Available in PDF
 
bulletJ. Porta, C. Kolar, S. G. Kozmin, Y. I. Pavlov and G. E. O. Borgstahl, "Structure of the orthorhombic form of human inosine triphosphate pyrophosphatase", Acta Cryst. (2006). F62, 1076-1081 Copyright © International Union of Crystallography
Available in PDF
 
bulletJ. J. Lovelace, C. R. Murphy, R. Pahl, K. Brister and G. E. O. Borgstahl, "Tracking reflections through cryogenic cooling with topography", J. Appl. Cryst. (2006). 39, 425-432
Copyright © International Union of Crystallography J. Appl. Cryst. 39, 425-432
Available in PDF
 
bulletJ. J. Lovelace and G. E. O. Borgstahl, "Ripple: a program to collect and analyze digital topographic sequences", J. Appl. Cryst. (2006). 39, 466-467
Copyright © International Union of Crystallography J. Appl. Cryst. 39, 466-467
Available in PDF
 
bulletJ. J. Lovelace, C. R. Murphy, H. D. Bellamy, K. Brister, R. Pahl and G. E. O. Borgstahl, "Advances in digital topography for characterizing imperfections in protein crystals", J. Appl. Cryst. (2005). 38, 512-519
Copyright © International Union of Crystallography J. Appl. Cryst. 38, 512-519
Available in PDF
 
bulletO. A. Asojo, G. Goud, K. Dhar, A. Loukas, Bin Zhan, Vehid Deumic, Sen Liu, G. E. O Borgstahl, P. J. Hotez, "X-ray structure of Na-ASP-2, a Pathogenesis Related-1 protein from the nematode parasite Necator americanus and a vaccine antigen for human hookworm infection" J. Mol Biol., 346(3): p801-814, 2005
Available in PDF
 
bulletF. Nachon, O. A. Asojo, G.E.O Borgstahl, P. Masson, and O. Lockridge, "Role of Water in Aging of Human Butyrylcholinesterase Inhibited by Echothiophate: The Crystal Structure Suggests Two Alternative Mechanisms of Aging" Biochemistry 44, 1154-1162 (2005)
Available in PDF
 
bulletLovelace, J. J., Soares, A. S.,  Bellamy, H. D., Sweet,  R. M., Snell, E. H. and Borgstahl, G. E. O. "First results of digital topography applied to macromolecular crystals" J. Appl. Cryst. (2004). 37, 481-485
Copyright © International Union of Crystallography J. Appl. Cryst. 37, 481-485
Available in PDF
 
bulletLovelace, J. J., Narayan, K., Chik, J. K., Bellamy, H. D., Snell, E. H., Lindberg, U., Schutt, C. E., and Borgstahl, G. E. O. "Imaging modulated reflections from a semi-crystalline state of profilin:actin crystals" J. Appl. Cryst. (2004). 37, 327-330
Copyright © International Union of Crystallography J. Appl. Cryst. 37, 327-330
Available in PDF
 
bulletVahedi-Faridi, A., Lovelace, J., Bellamy, H. D., Snell, E. H. and Borgstahl, G. E. O., "Physical and structural studies on the cryocooling of insulin crystals" Acta Cryst. (2003). D59, 2169-2182
Copyright © International Union of Crystallography Acta Cryst. D59, 2169-2182
Available in PDF
 
bulletLovelace, J. and Borgstahl, G. E. O. "BEAM-ish 2.0: a graphical user interface for the physical characterization of macromolecular crystals" J. Appl. Cryst. 36, 1101-1102 (2003).
Available in PDF
 
bulletVahedi-Faridi, A. , Porta, J.,  and Borgstahl, G. E. O. "Improved three-dimensional growth of manganese superoxide dismutase crystals on the International Space Station" Acta Cryst. (2003). D59, 385-388
Available in PDF
 
bulletSnell, E. H., Bellamy, H. D., and Borgstahl, G. E. O. "Macromolecular Crystal Quality" Methods in Enzymology, Macromolecular Crystallography, Part C, editors C. Carter and B. Sweet 368, 268-288 (2003).
Available in PDF
 
bulletJackson, D., Dhar, K., Wahl, J. K., Wold, M. S.,  and Borgstahl, G. E. O. "Analysis of the Human Replication Protein A:Rad52 Complex: Evidence for Crosstalk Between RPA32, RPA70, Rad52 and DNA" J. Mol. Biol. 321, 133-148 (2002).
Available in PDF
 
bulletRanatunga, W., Jackson, D., Flowers II, R. A. and Borgstahl, G. E. O. "Human Rad52 Protein Has Extreme Thermal Stability" Biochemistry 40, 8557-8562 (2001).
Available in PDF
 
bulletRanatunga, W., Jackson, D., Lloyd, J. A., Forget, A. L., Knight, K. L. and Borgstahl, G. E. O. "Human Rad52 Exhibits Two Modes of Self-association" J. Biol. Chem. 276, 15876-15880 (2001).
 Available in PDF
 
bulletBorgstahl, G. E. O., Vahedi-Faridi, A., Lovelace, J. J., Bellamy, H. and Snell, E. "A Test of Macromolecular Crystallization in Microgravity: Large, Well-ordered Insulin Crystals" Acta Cryst. D57, 1204-1207 (2001).
 Available in PDF
 
bulletSnell, E. H., Judge, R. A., Crawford, L., Pusey, M. L., Sporteillo, M., Todd, P. Bellamy, H. Lovelace, J., Cossanto, J. M. and Borgstahl, G. E., O. "Biochemical and X-ray Mosaicity Analysis of Impurity Doped Microgravity and Ground-grown Lysozyme Crystals" Crystal Growth & Design 1, 151-158 (2001).
 Available in PDF
 
bulletHabel, J. E., Ohren, J. F. and Borgstahl, G. E. O. "Dynamic light scattering analysis of full-length, human RPA14/32 dimer: purification crystallization and self-association" Acta Cryst. D57, 254-259 (2001).
 Available in PDF
 
bulletBellamy, H. D., Snell, E. H., Lovelace, J., Pokross, M. and Borgstahl, G. E. O. "The High Mosaicity Illusion: Revealing the True Physical Characteristics of Macromolecular Crystals" Acta Cryst. D56, 986-995 (2000).
Available in PDF

Errata #1 for Bellamy, et. al.
Available in PDF

Errata #2 for Bellamy, et. al.
Available in PDF
 

bulletLovelace, J. Snell, E. H., Pokross, M., Arvai, A. S., Nielsen, C., Xuong N.-H., Bellamy, H. D. and Borgstahl, G. E. O. "BEAM-ish: a graphical user interface for the physical characterization of macromolecular crystals" J. Appl. Cryst. 33, 1187-1188 (2000).
Available in PDF
 
bulletBorgstahl, G. E. O., Pokross, M., Chehab, R., Sekher, A. and Snell, E. H. "Cryo-trapping the Six-Coordinate, Distorted-Octahedral Active Site of Manganese Superoxide Dismutase" J. Mol. Biol. 296, 951-960 (2000).
Available in PDF
 
bulletGarlitz, J. A., Summers, C. A., Flowers II, R. A. and Borgstahl, G. E. O. "Ethylammonium Nitrate: A Protein Crystallization Reagent" Acta Cryst. D55, 2037-2038 (1999).
Available in PDF
 
bulletGuan, Y., Hickey, M. J., Borgstahl, G. E. O., Hallewell, R. A., Lepock, J. R., O'Connor, D. Hsieh, Y. Nick, H. S. Silverman, D. N. and Tainer, J. A. "Crystal Structure of Y34F Mutant Human Mitochondrial Manganese Superoxide Dismutase and the Functional Role of Tyrosine 34", Biochemistry 37, 4722-4730 (1998).
Available in PDF
 
bulletGenick, U.K.*, Borgstahl, G.E.O.*, Ng, K., Ren, Z., Pradervand, C., Burke, P.M., Srajer, V., Teng, T.Y., Schildkamp, W., McRee, D.E., Moffat, K., and Getzoff, E.D. "Millisecond Time-Resolved Laue Crystallography: Structure of a Protein Photocycle Intermediate", Science, 275, 1471-1475 (1997) *These authors contributed equally to this work.
Available in PDF
 
bulletRen, Z., Ng, K., Borgstahl, G. E. O., Getzoff, E. D., and Moffat, K. "Quantitative Analysis of Time-resolved Laue Diffraction Patterns", J. Appl. Cryst. 29, 246-260 (1996).
Available in PDF
 
bulletBorgstahl, G. E. O., Parge, H. E., Hickey, M. J., Johnson, M. J., Boissinot, M., Hallewell, R. A., Lepock, J. R., Cabelli, D. E. and Tainer, J. A. "Human Mitochondrial Manganese Superoxide Dismutase Polymorphic Variant Ile58Thr Reduces Activity by Destabilizing the Tetrameric Interface", Biochemistry, 35, 4287-4297 (1996).
Available in PDF
 
bulletBorgstahl, G. E. O., Williams, D. R., and Getzoff, E. D. "The 1.4 Å Structure of Photoactive Yellow Protein, a Cytosolic Photoreceptor: Unusual Fold, Active Site and Chromophore", Biochemistry, 34, 6278-6287 (1995).
Available in PDF
 
bulletBaca M., Borgstahl, G. E. O., Boissinot, M., Burke, P. M., Williams, D. R., Slater, K. A. and Getzoff, E. D. "Complete Chemical Structure of Photoactive Yellow Protein: Novel Thioester-linked 4-Hydroxycinnamyl Chromophore and Photocycle Chemistry", Biochemistry, 33, 14369-14377 (1994).
Available in PDF
 
bulletBorgstahl, G. E. O., Rogers, P. H., and Arnone, A. "The 1.9 Å Structure of Deoxyβ4 Hemoglobin: Analysis of the Partitioning of Quaternary-associated and Ligand-induced Changes in Tertiary Structure", J. Mol. Biol., 236, 831-843 (1994).
Available in PDF
 
bulletBorgstahl, G. E. O., Rogers, P. H., and Arnone, A. "The 1.8 Å Structure of Carbonmonoxy-β4 Hemoglobin: Characterization of the R-like Quaternary Structure", J. Mol. Biol., 236, 817-830 (1994).
Available in PDF
 
bulletBorgstahl, G. E. O., Parge, H. E., Hickey, M. J., Beyer, W. F., Hallewell, R. A. and Tainer, J. A. "The Structure of Human Manganese Superoxide Dismutase Reveals a Novel Tetrameric Interface of Two 4-helix Bundles", Cell, 71, 107-118 (1992).
Available in PDF
 

 

Counter provided by: www.digits.com

Visitors:

Last Updated: 04.15.2011

   © 2002-04 The UNMC Eppley Cancer Center - All Rights Reserved