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| Crystal Growth and Perfection ResultsThe group is also very interested in developing methods for the quantitative comparison of crystal quality. We employ to approaches. One experimental method(PDF) involves using highly-parallel, highly monochromatic synchrotron radiation, super-fine phi slicing and a CCD area detector to simultaneously measure mosaicity and diffraction resolution from hundreds of reflections at a time. These measurements can be used to quantitatively compare protein crystals grown from different methods, for example earth versus microgravity growth or the effects of impurities. We are continuing to develop these crystal quality methods and have written a graphical user interface program(PDF) for data processing called BEAM-ish. The second method is the use of digital topography to analyze internal crystal structure. A software program called Ripple is being developed to collect and analyze this data. This following pages highlight results on the implementation of an automatic system for the complete x-ray characterization of macromolecular crystals (BEAM-ish) and our digital topography system (Ripple). The majority of the pictures on the following pages were generated with our in house software program known as BEAM-ish. The 3-D reflection models were generated in Matlab with initial data provided from BEAM-ish. The animations were created using Microsoft's Gif animator. There are a substantial number of large animated gif files on the following pages and it is recommended that only people with high speed internet connections open those pages. We have noticed that under Internet Explorer some of the GIF animations are not displayed properly. It is recommended that the following pages are viewed with Netscape Navigator. The areas that are currently available are:
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